Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

Young Suk Yu; Hijai R. Shin; Dongha Kim; Seon Ah Baek; Seon Ah Choi; Hyejin Ahn; Amen Shamim; Jeonghwan Kim; Ik Soo Kim; Kyeong Kyu Kim; Kyoung-Jae Won; Sung Hee Baek

doi:10.1038/s41467-020-20080-9

Nature Communications (Dec 2020)

Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

Young Suk Yu,
Hijai R. Shin,
Dongha Kim,
Seon Ah Baek,
Seon Ah Choi,
Hyejin Ahn,
Amen Shamim,
Jeonghwan Kim,
Ik Soo Kim,
Kyeong Kyu Kim,
Kyoung-Jae Won,
Sung Hee Baek

Affiliations

Young Suk Yu: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Hijai R. Shin: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Dongha Kim: Department of Anatomy, College of Medicine, The Catholic University of Korea
Seon Ah Baek: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Seon Ah Choi: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Hyejin Ahn: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Amen Shamim: Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University
Jeonghwan Kim: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Ik Soo Kim: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University
Kyeong Kyu Kim: Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University
Kyoung-Jae Won: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Sung Hee Baek: Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University

DOI: https://doi.org/10.1038/s41467-020-20080-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Epigenetic regulations of autophagy have emerged as mechanisms for maintaining cellular homeostasis. Here the authors reveal that the CARM1-Pontin-FOXO3a signaling axis can activate autophagy related genes through enhancer activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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