Nature Communications (Sep 2024)
Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study
- Abhinav Thakral,
- John JW. Lee,
- Tianzhichao Hou,
- Katrina Hueniken,
- Tom Dudding,
- Mark Gormley,
- Shama Virani,
- Andrew Olshan,
- Brenda Diergaarde,
- Andrew R. Ness,
- Tim Waterboer,
- Karl Smith-Byrne,
- Paul Brennan,
- D. Neil Hayes,
- Eleanor Sanderson,
- M. Catherine Brown,
- Sophie Huang,
- Scott V. Bratman,
- Anna Spreafico,
- John De Almeida,
- Joel C. Davies,
- Laura Bierut,
- Gary J. Macfarlane,
- Pagona Lagiou,
- Areti Lagiou,
- Jerry Polesel,
- Antonio Agudo,
- Laia Alemany,
- Wolfgang Ahrens,
- Claire M. Healy,
- David I. Conway,
- Mari Nygard,
- Cristina Canova,
- Ivana Holcatova,
- Lorenzo Richiardi,
- Ariana Znaor,
- David P. Goldstein,
- Rayjean J. Hung,
- Wei Xu,
- Geoffrey Liu,
- Osvaldo Espin-Garcia
Affiliations
- Abhinav Thakral
- Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto
- John JW. Lee
- Department of Otolaryngology-Head and Neck Surgery, University of Toronto
- Tianzhichao Hou
- Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto
- Katrina Hueniken
- Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto
- Tom Dudding
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Mark Gormley
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Shama Virani
- Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization
- Andrew Olshan
- Department of Epidemiology, University of North Carolina
- Brenda Diergaarde
- Department of Human Genetics, School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center
- Andrew R. Ness
- University Hospitals Bristol and Weston NHS Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol
- Tim Waterboer
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Karl Smith-Byrne
- Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization
- Paul Brennan
- Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization
- D. Neil Hayes
- Division of Medical Oncology and Center for Cancer Research, University of Tennessee Health Science Center
- Eleanor Sanderson
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- M. Catherine Brown
- Princess Margaret Cancer Centre, University Health Network
- Sophie Huang
- Princess Margaret Cancer Centre, University Health Network
- Scott V. Bratman
- Princess Margaret Cancer Centre, University Health Network
- Anna Spreafico
- Princess Margaret Cancer Centre, University Health Network
- John De Almeida
- Department of Otolaryngology-Head and Neck Surgery, University of Toronto
- Joel C. Davies
- Department of Otolaryngology-Head and Neck Surgery, University of Toronto
- Laura Bierut
- Department of Psychiatry, Washington University School of Medicine
- Gary J. Macfarlane
- Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Pagona Lagiou
- Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian, University of Athens
- Areti Lagiou
- Department of Public and Community Health, School of Public Health, University of West Attica
- Jerry Polesel
- Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS
- Antonio Agudo
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Laia Alemany
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Wolfgang Ahrens
- Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany; Department of Mathematics and Computer Science, University of Bremen
- Claire M. Healy
- Department of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin
- David I. Conway
- School of Medicine, Dentistry, and Nursing, University of Glasgow
- Mari Nygard
- Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health
- Cristina Canova
- University of Padua
- Ivana Holcatova
- Institute of Hygiene & Epidemiology, 1st Faculty of Medicine, Charles University
- Lorenzo Richiardi
- Department of Medical Sciences, University of Turin and CPO-Piemonte
- Ariana Znaor
- Cancer Surveillance Branch, International Agency for Research on Cancer, World Health Organization
- David P. Goldstein
- Department of Otolaryngology-Head and Neck Surgery, University of Toronto
- Rayjean J. Hung
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health
- Wei Xu
- Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto
- Geoffrey Liu
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Osvaldo Espin-Garcia
- Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-024-51679-x
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 9
Abstract
Abstract HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI:1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI:1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI:3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI:1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
