Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive

Erin W. Meermeier; Christina L. Zheng; Jessica G. Tran; Shogo Soma; Aneta H. Worley; David I. Weiss; Robert L. Modlin; Gwendolyn Swarbrick; Elham Karamooz; Sharon Khuzwayo; Emily B. Wong; Marielle C. Gold; David M. Lewinsohn

doi:10.1038/s42003-022-03823-w

Communications Biology (Sep 2022)

Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive

Erin W. Meermeier,
Christina L. Zheng,
Jessica G. Tran,
Shogo Soma,
Aneta H. Worley,
David I. Weiss,
Robert L. Modlin,
Gwendolyn Swarbrick,
Elham Karamooz,
Sharon Khuzwayo,
Emily B. Wong,
Marielle C. Gold,
David M. Lewinsohn

Affiliations

Erin W. Meermeier: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University
Christina L. Zheng: Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University
Jessica G. Tran: VA Portland Health Care System
Shogo Soma: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University
Aneta H. Worley: VA Portland Health Care System
David I. Weiss: David Geffen School of Medicine at UCLA
Robert L. Modlin: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles
Gwendolyn Swarbrick: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University
Elham Karamooz: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University
Sharon Khuzwayo: Africa Health Research Institute
Emily B. Wong: Africa Health Research Institute
Marielle C. Gold: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University
David M. Lewinsohn: Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University

DOI: https://doi.org/10.1038/s42003-022-03823-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Human lung-resident MAIT cells are distinct from CD8+ T cells. They are polycytotoxic, secrete the directly antimicrobial molecule IL-26, express genes associated with persistence, and selectively express interferon-γ- and IL-12- receptors.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal