Infection and Drug Resistance (Aug 2022)

Antimicrobial Resistance Trends of the Most Common Causative Pathogens Associated with Community-acquired Respiratory Infections in China: 2009–2018

  • Zhao C,
  • Yang S,
  • Zhang F,
  • Wang Z,
  • Zhang Y,
  • Wang X,
  • Li H,
  • Chen H,
  • Wang H

Journal volume & issue
Vol. Volume 15
pp. 5069 – 5083

Abstract

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Chunjiang Zhao, Shuo Yang, Feifei Zhang, Zhanwei Wang, Yawei Zhang, Xiaojuan Wang, Henan Li, Hongbin Chen, Hui Wang Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Hui Wang, Department of Clinical Laboratory, Peking University People’s Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Email [email protected]: Emergence of antimicrobial resistance poses new challenges in the management of community acquired respiratory tract infections (CARTIs). Therefore, surveillance on the antimicrobial susceptibilities of common respiratory pathogens is valuable and guides empirical therapeutic choices in management of CARTIs.Objective: The objective of the current study is to summarize the antimicrobial resistance trends in common respiratory tract pathogens isolated from patients with CARTIs in China, over a 10-year period (2009– 2018).Methods: Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis strains were collected from multicenter, and antimicrobial susceptibility testing was performed in the research central laboratory of each study period from 2009– 2018. The pathogens that accounted for CARTIs in the adult population was considered and summarized.Results: From 2009– 2018 a total of 3750 isolates were collected from 22 cities located across different regions of China. Among these the most common bacterial isolates include S. pneumoniae (53.7%) followed by H. influenza (32.4%), M. catarrhalis (13.9%). S. pneumoniae exhibited reduction in susceptibility and increase in resistance to penicillin, cephalosporins (cefaclor, cefuroxime, ceftriaxone) during the surveillance period. Invasive and noninvasive S. pneumoniae showed similar resistance. In the case of H. influenzae susceptibility to β-lactam and β-lactamase inhibitors (ampicillin, amoxicillin and AMC), SXT, clarithromycin and cephalosporins (cefuroxime, cefaclor, ceftazidime) was reduced over the past 10 years with an exception of ceftriaxone. Overall, moxifloxacin and levofloxacin have the highest susceptibility rates against S. pneumoniae (> 95%) and H. influenza (> 90%). M. catarrhalis exhibited susceptibility to almost all the tested antimicrobials.Conclusion: In China the 10-year trends showed a substantial increase in resistance to β-lactam drugs and reduction in sensitivity. However, certain antimicrobial agents namely fluoroquinolones including moxifloxacin and levofloxacin maintained low resistance rates with better susceptibility. Further, with few exceptions decline in susceptibility rates to macrolides and cephalosporins was observed among the tested pathogens.Keywords: Community-acquired respiratory tract infections, antimicrobial resistance, susceptibility, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis

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