ASSOCIATION OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELET-TO-LYMPHOCYTE RATIO, AND SYSTEMIC IMMUNE-INFLAMMATION INDEX WITH THE DEGREE OF ADENOID HYPERTROPHY IN CHILDREN

Abstract

Objective To investigate the association of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) with the degree of adenoid hypertrophy in children. Methods This study was conducted for 181 children who attended Department of Otorhinolaryngology & Head and Neck Surgery in our hospital and were diagnosed with adenoid hypertrophy by fibrolaryngoscopy from February 2020 to February 2021. According to the type and degree of adenoid hypertrophy, the children were divided into pathological adenoid hypertrophy (degree Ⅲ-Ⅳ hypertrophy) group and physiological adenoid hypertrophy (degree Ⅰ-Ⅱhypertrophy) group (group A), and the pathological adenoid hypertrophy group was further divided into degree Ⅲ hypertrophy group (group B) and degree Ⅳ hypertrophy group (group C). Plasma NLR, PLR, and SII were compared between the above groups, and the influence of these indices on the degree of adenoid hypertrophy in children were analyzed. Results There were significant differences in plasma NLR and SII between the three groups (F=27.346, 22.533,P<0.001), while there was no significant difference in plasma PLR between the three groups (P>0.05); group C had significantly higher plasma NLR and SII than groups A and B (P<0.05), and group B had significantly higher plasma NLR and SII than group A (P<0.05). The receiver operating characteristic (ROC) curve analysis showed that plasma NLR and SII had an area under the ROC curve of 0.809 and 0.763, respectively, in the diagnosis of pathological adenoid hypertrophy, and NLR had a sensitivity of 93.85% and a specificity of 52.94%, while SII had a sensitivity of 42.31% and a specificity of 98.04%. Plasma NLR ≥0.57 and/or SII ≥356.41 might suggest the possibility of pathological adenoid hypertrophy (degree Ⅲ or above). Conclusion Plasma NLR and SII are correlated with the degree of adenoid hypertrophy in children and can thus be used as simple refe-rence indices for predicting pathological adenoid hypertrophy.

Keywords

• adenoids|hypertrophy|neutrophils|lymphocyte count|platelet count