International Journal of COPD (Aug 2024)
Association Between Dietary Selenium Intake and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study from the National Health and Nutrition Examination Survey 1999–2018
Abstract
Chengfeng Fu,1,* Junwei Shi,2,* Ying Hu,1 Jing Luo1 1Respiratory and Critical Care Medicine, the Second People’s Hospital of Banan District, Chongqing, 400054, People’s Republic of China; 2State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Luo, Respiratory and Critical Care Medicine, the Second People’s Hospital of Banan District, Chongqing, 400054, People’s Republic of China, Tel +86 15823143609, Email [email protected]: Chronic obstructive pulmonary disease (COPD) is a widespread respiratory condition characterized by chronic inflammation. Selenium, an essential trace element, possesses anti-inflammatory and antioxidant properties. However, the diet is often complex, and the absence of one nutrient may indicate a concurrent deficiency in others. Therefore, inadequate dietary selenium intake may suggest deficiencies in other elements. Despite its potential benefits, there is a scarcity of evidence regarding the association between dietary selenium intake and COPD.Purpose: This study aims to investigate the potential association between dietary selenium intake and COPD among American adults.Patients and Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey conducted in the United States from 1999 to 2018. Multivariate logistic regression, restricted cubic spline analyses, subgroup analysis, and sensitivity analysis were conducted to assess the correlation between dietary selenium intake and COPD.Results: A total of 39,654 participants were included in the study. The adjusted odds ratio (OR) for COPD in the highest selenium intake group (T3, > 122.0 μg/day) was 0.80 (95% CI: 0.71– 0.91, p < 0.001) compared to the lowest intake group (T1, < 81.6 μg/day). Dietary selenium intake exhibited a linear negative correlation with COPD. Among participants reporting selenium supplementation, a similar negative association persisted.Conclusion: This study observed a negative correlation between dietary selenium intake and COPD among American adults, indicating a possible association between higher selenium intake and a lower risk of COPD.Keywords: cross-sectional study, chronic obstructive pulmonary disease, COPD, dietary selenium intake, National Health and Nutrition Examination Survey, NHANES
