Nature Communications (Aug 2016)

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

  • Ludovic Sauguet,
  • Pierre Raia,
  • Ghislaine Henneke,
  • Marc Delarue

DOI
https://doi.org/10.1038/ncomms12227
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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The structures of many DNA polymerases is known, but PolD was a missing piece. Here, the authors report the crystal structure of this protein and use it to connect the DNA replication machinery with the transcription machinery in the same protein family.