Biology (Feb 2021)

Systematic Review of Effectiveness of Chitosan as a Biofunctionalizer of Titanium Implants

  • Nansi López-Valverde,
  • Antonio López-Valverde,
  • Juan Manuel Ramírez

DOI
https://doi.org/10.3390/biology10020102
Journal volume & issue
Vol. 10, no. 2
p. 102

Abstract

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Chitosan is a natural polysaccharide extracted from the shells of crustaceans that has been proposed as a scaffold in tissue engineering. Certain studies have proven a greater osseointegration of titanium surfaces that are functionalized with chitosan. The MEDLINE, CENTRAL, PubMed, and Web of Science databases were electronically searched for in vivo studies. Seven studies met the inclusion criteria. Animal models, implant site, chitosan incorporation methods, and methods of analysis were emphasized. The selected studies were individually discussed regarding the coatings, osseointegration potential, and suitability of the experimental models used, analyzing their limitations. We concluded that chitosan-biofunctionalized titanium surfaces have greater osseointegration capacity that uncoated control titanium alloys.

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