Eukaryotic translation initiation factor 3 subunit B promotes head and neck cancer via CEBPB translation

Chengzhi Xu; Yupeng Shen; Yong Shi; Ming Zhang; Liang Zhou

doi:10.1186/s12935-022-02578-y

Cancer Cell International (Apr 2022)

Eukaryotic translation initiation factor 3 subunit B promotes head and neck cancer via CEBPB translation

Chengzhi Xu,
Yupeng Shen,
Yong Shi,
Ming Zhang,
Liang Zhou

Affiliations

Chengzhi Xu: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University
Yupeng Shen: Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Hebei Medical University
Yong Shi: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University
Ming Zhang: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University
Liang Zhou: Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University

DOI: https://doi.org/10.1186/s12935-022-02578-y
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 12

Abstract

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Highlights EIF3B is a prognostic biomarker for HNSCC risk; EIF3B promotes HNSCC progression in vitro and in vivo; EIF3B promotes CEBPB translation and activates the MAPK pathway; IL6R and CCNG2 are targets of EIF3B-regulated CEBPB translation.

Published in Cancer Cell International

ISSN: 1475-2867 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://cancerci.biomedcentral.com

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Abstract

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