精准医学杂志 (Dec 2023)

THE EXPRESSION AND SIGNIFICANCE OF SERUM TRAb, TSAb, AND TSBAb IN PATIENTS WITH HASHIMOTO’S THYROIDITIS WITH HYPOTHYROIDISM

  • XUE Yu, JIA Zhenyan, DU Yunsai, GONG Qian, DU Wenhua, GAO Guanqi

DOI
https://doi.org/10.13362/j.jpmed.202306005
Journal volume & issue
Vol. 38, no. 6
pp. 490 – 493

Abstract

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Objective To investigate the changes in serum thyrotropin receptor antibody (TRAb), thyroid stimulating antibody (TSAb), and thyroid-stimulating blocking antibody (TSBAb) and their significance in patients with Hashimoto’s thyroiditis with hypothyroidism (HT hypothyroidism). Methods A total of 133 patients with HT hypothyroidism (HT hypothyroidism group) and 125 healthy subjects (control group) were enrolled and their clinical data were collected. The serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), and TRAb were measured and compared between the two groups. TSAb and TSBAb were also compared across the patients who were positive for TRAb (group B), who were negative for TRAb (group C), and the healthy subjects who were negative for TRAb (group A). A Pearson correlation analysis was used to examine the relationships between the serum levels of TSAb and TSBAb and the serum levels of FT3, FT4, TSH, and TRAb in patients with HT hypothyroidism. Results The serum TRAb level in the HT hypothyroidism group was significantly higher than that in the control group (Z=-5.434,P<0.05). Compared with group A, group B showed significantly higher serum levels of TRAb and TSBAb and positive rate of serum TSBAb (Z=6.228,F=17.985,t=7.767,χ2=15.273,P<0.05); compared with group C, group B had significantly higher serum levels of TRAb and TSBAb and positive rates of serum TSAb and TSBAb (Z=5.732,F=17.985,t=7.056,χ2=62.115,52.000,P<0.05). The Pearson correlation analysis showed that the serum TSBAb level in patients with HT hypothyroidism was positively correlated with their serum TRAb level (r=0.756,P<0.05). Conclusion The increased expression of TSBAb in serum may be an important factor in the pathogenesis of HT hypothyroidism. For HT hypothyroidism patients with positive serum TRAb, attention should be paid to the measurement of their serum TSBAb expression.

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