Nature Communications (Apr 2021)

Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions

  • Valentina Palmerini,
  • Silvia Monzani,
  • Quentin Laurichesse,
  • Rihab Loudhaief,
  • Sara Mari,
  • Valentina Cecatiello,
  • Vincent Olieric,
  • Sebastiano Pasqualato,
  • Julien Colombani,
  • Ditte S. Andersen,
  • Marina Mapelli

DOI
https://doi.org/10.1038/s41467-021-22080-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.