Lselectin Levels in Patients with Endometriosis

Abstract

Objective: To investigate the L-selectin profile in endometriotic patients. Methods: This was a cross-sectional study. Subjects were patients diagnosed endometriosis based on clinical examination, transvaginal ultrasound, MRI and CT scan at the Department of Obstetrics and Gynecology of Prof. Dr. R.D. Kandou Hospital Manado, Siloam Hospital and Network Hospital starting from January 2017 to May 2017. The blood samples in patients prior to surgery were taken on a vein and then separated to obtain serum. Further more, serum levels of L-selectin were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed with SPSS version 22.0 to see significance level. Results: Of the 18 samples, based on age, endometriosis highest in the group > 26 years ie 17 patients (94.44%), followed by the age group of 21-25 years in 1 patient (5:56%), and none of the patients in the age group 4 (0%). Based on the highest stage is the third stage as many as 11 people (61.11%), followed by stage 4 of 7 patients (38.99%), and none of the patients in stage 1 or stage 2 (0%). From a statistical test used to stage endometriosis age, the T test, p value 0.286. From a statistical test according to the levels of L-selectin on endometriosis stadium used, the T test, p value 0.090. Results of correlation tests were used, namely stating Pearson test p value of 0.921. Conclusion: L-selectin levels in women with endometriosis increased according to clinical stage, but not significant in statistical tests. There is no significant relationship between age with stages or levels of L-selectin in women with endometriosis. Keywords: adhesion, age, endometriosis, L-selectin, stage