Oncology Reviews (Mar 2018)

The impact of Mir-9 regulation in normal and malignant hematopoiesis

  • Abbas Khosravi,
  • Shaban Alizadeh,
  • Arsalan Jalili,
  • Reza Shirzad,
  • Najmaldin Saki

DOI
https://doi.org/10.4081/oncol.2018.348
Journal volume & issue
Vol. 12, no. 1

Abstract

Read online

MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias. Our findings indicated MiR-9 downregulation in a majority of leukemias. However, its overexpression was reported in patients with dysregulated MiR-9 controlling factors (such as MLLr). Additionally, prognostic value of MiR-9 has been reported in some types of leukemia. This study generally emphasizes on the critical role of MiR-9 in hematologic malignancies as a prognostic factor and a therapeutic target.

Keywords