Journal of Clinical Medicine (Jul 2022)
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU
- Sabino Riestra,
- Carlos Taxonera,
- Yamile Zabana,
- Daniel Carpio,
- María Chaparro,
- Jesús Barrio,
- Montserrat Rivero,
- Antonio López-Sanroman,
- María Esteve,
- Ruth de Francisco,
- Guillermo Bastida,
- Santiago García-López,
- Miriam Mañosa,
- María Dolores Martin-Arranz,
- José Lázaro Pérez-Calle,
- Jordi Guardiola,
- Fernando Muñoz,
- Laura Arranz,
- José Luis Cabriada,
- Mariana Fe García-Sepulcre,
- Mercè Navarro,
- Miguel Ángel Montoro-Huguet,
- Elena Ricart,
- Fernando Bermejo,
- Xavier Calvet,
- Marta Piqueras,
- Esther Garcia-Planella,
- Lucía Márquez,
- Miguel Mínguez,
- Manuel Van Domselar,
- Luis Bujanda,
- Xavier Aldeguer,
- Beatriz Sicilia,
- Eva Iglesias,
- Guillermo Alcaín,
- Isabel Pérez-Martínez,
- Valeria Rolle,
- Andrés Castaño-García,
- Javier P. Gisbert,
- Eugeni Domènech,
- on behalf of the ENEIDA registry from GETECCU
Affiliations
- Sabino Riestra
- Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Carlos Taxonera
- Gastroenterology Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
- Yamile Zabana
- Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain
- Daniel Carpio
- Gastroenterology Department, Complexo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain
- María Chaparro
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Jesús Barrio
- Gastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain
- Montserrat Rivero
- Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain
- Antonio López-Sanroman
- Gastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- María Esteve
- Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain
- Ruth de Francisco
- Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Guillermo Bastida
- Gastroenterology Department, Hospital Universitari i Politecnic La Fe, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 46026 Valencia, Spain
- Santiago García-López
- Gastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain
- Miriam Mañosa
- Gastroenterology Department, Hospital Universitari Germans Trials i Pujol, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08916 Badalona, Spain
- María Dolores Martin-Arranz
- Gastroenterology Department, Hospital Universitario La Paz, Instituto de Investigación Sanitaria del Hospital La Paz (IdiPAZ), 28046 Madrid, Spain
- José Lázaro Pérez-Calle
- Gastroenterology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain
- Jordi Guardiola
- Gastroenterology Department, Hospital Universitario de Bellvitge, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), 08907 Barcelona, Spain
- Fernando Muñoz
- Gastroenterology Department, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
- Laura Arranz
- Gastroenterology Department, Hospital Nuestra Señora de la Candelaria, 38010 Tenerife, Spain
- José Luis Cabriada
- Gastroenterology Department, Hospital de Galdakao-Usansolo, 48960 Galdakao, Spain
- Mariana Fe García-Sepulcre
- Gastroenterology Department, Hospital General Universitario de Elche, 03203 Alicante, Spain
- Mercè Navarro
- Gastroenterology Department, Hospital Sant Joan Despí-Moisès Broggi, 08970 Barcelona, Spain
- Miguel Ángel Montoro-Huguet
- Gastroenterology Department, Hospital San Jorge, 22004 Huesca, Spain
- Elena Ricart
- Gastroenterology Department, Hospital Clinic i Provincial, IDIBAPS, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08036 Barcelona, Spain
- Fernando Bermejo
- Gastroenterology Department, Hospital Universitario de Fuenlabrada, Instituto de Investigación Sanitaria Hospital La Paz (IdiPaz), 28942 Madrid, Spain
- Xavier Calvet
- Gastroenterology Department, Hospital Universitari Parc Taulí, Depàrtament de Medicina Universitat Autònoma de Barcelona, Sabadell, CIBERehd, 08208 Sabadell, Spain
- Marta Piqueras
- Gastroenterology Department, Consorcio Sanitario de Terrasa, 08227 Barcelona, Spain
- Esther Garcia-Planella
- Gastroenterology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
- Lucía Márquez
- Gastroenterology Department, Hospital del Mar, Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, Spain
- Miguel Mínguez
- Gastroenterology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain
- Manuel Van Domselar
- Gastroenterology Department, Hospital Universitario de Torrejón, 28850 Madrid, Spain
- Luis Bujanda
- Gastroenterology Department, Hospital Universitario de Donostia/Biodonostia, Universidad del País Vasco (UPV/EHU), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 20014 San Sebastián, Spain
- Xavier Aldeguer
- Gastroenterology Department, Hospital Universitario de Girona Dr Josep Trueta, 17007 Girona, Spain
- Beatriz Sicilia
- Gastroenterology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain
- Eva Iglesias
- Gastroenterology Department, Hospital Reina Sofía, IMIBIC, 14004 Córdoba, Spain
- Guillermo Alcaín
- Gastroenterology Department, Hospital Clínico de Málaga, 29010 Málaga, Spain
- Isabel Pérez-Martínez
- Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Valeria Rolle
- Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Andrés Castaño-García
- Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain
- Javier P. Gisbert
- Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Eugeni Domènech
- Gastroenterology Department, Hospital Universitari Germans Trials i Pujol, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08916 Badalona, Spain
- on behalf of the ENEIDA registry from GETECCU
- DOI
- https://doi.org/10.3390/jcm11133915
- Journal volume & issue
-
Vol. 11,
no. 13
p. 3915
Abstract
(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18–20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50–0.73, p p p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
Keywords
- inflammatory bowel disease
- latent tuberculosis infection
- tuberculin skin test
- interferon gamma release assays