CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee; Nan-Shih Liao

Journal of Microbiology, Immunology and Infection (Jun 2021)

CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee,
Nan-Shih Liao

Affiliations

Gilbert Aaron Lee: Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan; Corresponding author. Department of Medical Research, Taipei Medical University Hospital, No.252 Wu Hsing Street, Taipei City, 110, Taiwan.
Nan-Shih Liao: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

Journal volume & issue: Vol. 54, no. 3
pp. 514 – 517

Abstract

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The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

Published in Journal of Microbiology, Immunology and Infection

ISSN: 1684-1182 (Print)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Science: Microbiology
Website: https://www.sciencedirect.com/journal/journal-of-microbiology-immunology-and-infection

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