Plasma Level of Oxidized Low- Density Lipoprotein in Macroalbuminuric

Abstract

Accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. To evaluate the association of oxidized low- density lipoprotein (ox-LDL) with the development of diabetic nephropathy, plasma level of ox-LDL were measured in 70 diabetic patients with macro and 63 patients with normoalbuminuria. The plasma oxidized- LDL level in patients with macroalbuminuria was higher than those in normoalbuminuric group, (85.72 ± 32.92 mu/L versus 75.07 ± 26.46 u/L, P= 0.041). hemoglobin A1C (HbA1C) levels were similar in diabetic patients with macro (9.0 ± 1.80%) and normoalbuminuria (8.52 ± 1.7%, P= 0.098). There was no significant correlation between the ox-LDL and HbA1C level. The significantly elevated plasma oxidized- LDL in patients with macroalbuminuria suggests that ox-LDL may play an important role in the progression of diabetic nephropathy.

Keywords

• Diabetic nephropathy
• oxidized low- density lipoprotein