Advanced Pharmaceutical Bulletin (Mar 2022)

Mesenchymal Stem Cells in the Treatment of New Coronavirus Pandemic: A Novel Promising Therapeutic Approach

  • Sara Razi,
  • Zahra Molavi,
  • Seyed Amir Mirmotalebisohi,
  • Zahra Niknam,
  • Marzieh Sameni,
  • Vahid Niazi,
  • Amirjafar Adibi,
  • Mohsen Yazdani,
  • Mohammad Mehdi Ranjbar,
  • Hakimeh Zali

DOI
https://doi.org/10.34172/apb.2022.023
Journal volume & issue
Vol. 12, no. 2
pp. 206 – 216

Abstract

Read online

After severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks, coronavirus disease 2019 (COVID-19) is the third coronavirus epidemic that soon turned into a pandemic. This virus causes acute respiratory syndrome in infected people. The mortality rate of SARS-CoV-2 infection will probably rise unless efficient treatments or vaccines are developed. The global funding and medical communities have started performing more than five hundred clinical examinations on a broad spectrum of repurposed drugs to acquire effective treatments. Besides, other novel treatment approaches have also recently emerged, including cellular host-directed therapies. They counteract the unwanted responses of the host immune system that led to the severe pathogenesis of SARS-CoV-2. This brief review focuses on mesenchymal stem cell (MSC) principles in treating the COVID-19. The US clinical trials database and the world health organization database for clinical trials have reported 82 clinical trials (altogether) exploring the effects of MSCs in COVID-19 treatment. MSCs also had better be tried for treating other pathogens worldwide. MSC treatment may have the potential to end the high mortality rate of COVID-19. Besides, it also limits the long-term inability of survivors.

Keywords