Nature Communications (Feb 2019)
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
- Yue Gu,
- Yee Hwa Wong,
- Chong Wai Liew,
- Conrad E. Z. Chan,
- Tanusya M. Murali,
- Jiawei Yap,
- Chien Tei Too,
- Kiren Purushotorman,
- Maryam Hamidinia,
- Abbas El Sahili,
- Angeline T. H. Goh,
- Rachel Z. C. Teo,
- Kathryn J. Wood,
- Brendon J. Hanson,
- Nicholas R. J. Gascoigne,
- Julien Lescar,
- Anantharaman Vathsala,
- Paul A. MacAry
Affiliations
- Yue Gu
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Yee Hwa Wong
- School of Biological Sciences, Nanyang Technological University
- Chong Wai Liew
- NTU Institute of Structural Biology, Nanyang Technological University
- Conrad E. Z. Chan
- DSO National Laboratories
- Tanusya M. Murali
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Jiawei Yap
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Chien Tei Too
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Kiren Purushotorman
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Maryam Hamidinia
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Abbas El Sahili
- School of Biological Sciences, Nanyang Technological University
- Angeline T. H. Goh
- National University Centre for Organ Transplantation (NUCOT), National University Hospital
- Rachel Z. C. Teo
- National University Centre for Organ Transplantation (NUCOT), National University Hospital
- Kathryn J. Wood
- Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
- Brendon J. Hanson
- DSO National Laboratories
- Nicholas R. J. Gascoigne
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Julien Lescar
- School of Biological Sciences, Nanyang Technological University
- Anantharaman Vathsala
- National University Centre for Organ Transplantation (NUCOT), National University Hospital
- Paul A. MacAry
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-019-08790-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.
