G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Malarvizhi Gurusamy; Denise Tischner; Jingchen Shao; Stephan Klatt; Sven Zukunft; Remy Bonnavion; Stefan Günther; Kai Siebenbrodt; Roxane-Isabelle Kestner; Tanja Kuhlmann; Ingrid Fleming; Stefan Offermanns; Nina Wettschureck

doi:10.1038/s41467-021-26882-9

Nature Communications (Nov 2021)

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Malarvizhi Gurusamy,
Denise Tischner,
Jingchen Shao,
Stephan Klatt,
Sven Zukunft,
Remy Bonnavion,
Stefan Günther,
Kai Siebenbrodt,
Roxane-Isabelle Kestner,
Tanja Kuhlmann,
Ingrid Fleming,
Stefan Offermanns,
Nina Wettschureck

Affiliations

Malarvizhi Gurusamy: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Denise Tischner: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Jingchen Shao: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Stephan Klatt: Centre of Molecular Medicine, Goethe University
Sven Zukunft: Centre of Molecular Medicine, Goethe University
Remy Bonnavion: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Stefan Günther: Deep sequencing platform, Max Planck Institute for Heart and Lung Research
Kai Siebenbrodt: Department of Neurology, University of Frankfurt
Roxane-Isabelle Kestner: Department of Neurology, University of Frankfurt
Tanja Kuhlmann: Institute of Neuropathology, University of Münster
Ingrid Fleming: Centre of Molecular Medicine, Goethe University
Stefan Offermanns: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Nina Wettschureck: Department of Pharmacology, Max Planck Institute for Heart and Lung Research

DOI: https://doi.org/10.1038/s41467-021-26882-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocrine/paracrine loop.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal