Cancer Management and Research (Nov 2021)

Survival Effects of Radiotherapy on Patients Newly Diagnosed with Distant Metastatic Nasopharyngeal Carcinoma in Non-High-Incidence Areas

  • Yang Y,
  • Li X,
  • Zhou P,
  • Deng X,
  • Wang Y,
  • Dang Q,
  • Zheng Y,
  • Yang D

Journal volume & issue
Vol. Volume 13
pp. 8169 – 8178

Abstract

Read online

Yongqiang Yang, Xiaole Li, Pengcheng Zhou, Xiaoyu Deng, Yingyi Wang, Qianqian Dang, Yingjuan Zheng, Daoke Yang Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yingjuan Zheng; Daoke YangDepartment of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450052, Henan Province, People’s Republic of ChinaTel +86-15738872856; +86-15903650068Email [email protected]; [email protected]: To analyze the effects of radiotherapy and its timing on the survival and safety of patients with newly diagnosed distant metastatic NPC in non-high-incidence areas.Patients and Methods: We retrospectively analyzed 94 newly diagnosed NPC patients with distant metastatic admitted to our hospital from January 2011 to June 2018. They were divided into three groups: no radiotherapy group received chemotherapy alone, early radiotherapy group was combined with radiotherapy during 1 to 3 cycles of chemotherapy, and late radiotherapy group was combined with radiotherapy after 4– 6 cycles of chemotherapy were effective. The efficacy and side effects of the three groups were compared, and the prognostic factors were analyzed.Results: The 6-month, 1-year and 2-year PFS were 53.6%, 14.3% and 3.6% in no radiotherapy group, 71.0%, 38.7% and 19.4% in early radiotherapy group, 88.6%, 48.6% and 22.9% in late radiotherapy group; the radiotherapy groups were better than the no radiotherapy group, and the difference was statistically significant (P 0.017).Conclusion: Early and late combined radiotherapy had similar clinical efficacy and both prolonged PFS and OS for patients with newly diagnosed distant metastatic NPC in non-high-risk areas. If chemotherapy response is expected to be poor, radiotherapy can be received early.Keywords: radiotherapy, nasopharyngeal carcinoma, metastasis, non-high-incidence area, prognosis

Keywords