Journal of Experimental Pharmacology (Jan 2024)
The Effects of Potato (Solanum tuberosum L. vs. Granola; Solanaceae) Peel Extract Gel on Gingival Wound Healing in Wistar Rats
Abstract
Faradila Tiarasanti,1,* Irna Sufiawati,1,* Eri Amalia,2 Kartika Indah Sari,3 Cucu Zubaedah,4 Veni Takarini5 1Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia; 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia; 3Department of Oral Biology, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia; 4Department of Dental Public Health, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia; 5Department of Dental Material Science and Technology, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia*These authors contributed equally to this workCorrespondence: Irna Sufiawati, Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Jalan Sekeloa No. 1, Bandung, West Java, 40132, Indonesia, Tel +62-22-2504985, Email [email protected]: Phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties have been identified in potatoes (Solanum tuberosum L.; Solanaceae), which may potentially contribute to wound healing. The study aimed to evaluate the effect of potato peel extract gel Granola variety on oral gingival wound healing in Wistar Rats.Methods: This research was a true experimental in vivo study, involving 30 male Wistar rats, aged 12– 14 weeks and weighing approximately 150 to 200 grams. Surgical vertical incisions, each 3 mm in length, were made on the mandibular gingiva. The test group consisted of six subgroups, each comprising 5 rats. The negative control group received a base gel, while treatment groups were given 1% povidone-iodine solution, 0.1% triamcinolone acetonide oral paste, and 2%, 4%, and 6% potato peel extract gel. Wound lengths were measured on days 3, 7, and 14 to evaluate the healing process. Statistical analysis used the ANOVA test, a p-value of < 0.05 was considered statistically significant.Results: All experimental groups showed a reduction in wound length on days 3, 7, and 14. Notably, the application of 4% and 6% potato peel extract gel formulations facilitated to faster wound healing on day 3, surpassing the povidone-iodine and triamcinolone acetonide groups. However, by days 7 and 14, both the povidone-iodine group and the 6% formulation group demonstrated superior outcomes, although the differences in values were not statistically significant (p < 0.05).Conclusion: Potato peel extract gel formulations at 4% and 6% concentrations were found to expedite the healing of incision wounds, showing no statistically significant difference from the povidone-iodine and triamcinolone acetonide groups. Therefore, potato peel extract gel holds excellent potential for development as an alternative medicine for natural and safe wound healing therapy.Keywords: potato peel extract, gel, wound healing
