Satellite glial cells promote regenerative growth in sensory neurons

Oshri Avraham; Pan-Yue Deng; Sara Jones; Rejji Kuruvilla; Clay F. Semenkovich; Vitaly A. Klyachko; Valeria Cavalli

doi:10.1038/s41467-020-18642-y

Nature Communications (Sep 2020)

Satellite glial cells promote regenerative growth in sensory neurons

Oshri Avraham,
Pan-Yue Deng,
Sara Jones,
Rejji Kuruvilla,
Clay F. Semenkovich,
Vitaly A. Klyachko,
Valeria Cavalli

Affiliations

Oshri Avraham: Department of Neuroscience, Washington University School of Medicine
Pan-Yue Deng: Department of Cell Biology and Physiology, Washington University School of Medicine
Sara Jones: Department of Neuroscience, Washington University School of Medicine
Rejji Kuruvilla: Department of Biology, Johns Hopkins University
Clay F. Semenkovich: Department of Cell Biology and Physiology, Washington University School of Medicine
Vitaly A. Klyachko: Department of Cell Biology and Physiology, Washington University School of Medicine
Valeria Cavalli: Department of Neuroscience, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-18642-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axon regeneration via Fasn-PPARα signalling pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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