Experimental and Molecular Medicine (Apr 2024)
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
- Yeajina Lee,
- Tamrin Chowdhury,
- Sojin Kim,
- Hyeon Jong Yu,
- Kyung-Min Kim,
- Ho Kang,
- Min-Sung Kim,
- Jin Wook Kim,
- Yong-Hwy Kim,
- So Young Ji,
- Kihwan Hwang,
- Jung Ho Han,
- Jinha Hwang,
- Seong-Keun Yoo,
- Kyu Sang Lee,
- Gheeyoung Choe,
- Jae-Kyung Won,
- Sung-Hye Park,
- Yong Kyu Lee,
- Joo Heon Shin,
- Chul-Kee Park,
- Chae-Yong Kim,
- Jong-Il Kim
Affiliations
- Yeajina Lee
- Department of Biomedical Sciences, Seoul National University Graduate School
- Tamrin Chowdhury
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Sojin Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Hyeon Jong Yu
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Kyung-Min Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Ho Kang
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Min-Sung Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Jin Wook Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- Yong-Hwy Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital
- So Young Ji
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Kihwan Hwang
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Jung Ho Han
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Jinha Hwang
- Department of Laboratory Medicine, Korea University Anam Hospital
- Seong-Keun Yoo
- The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Kyu Sang Lee
- Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Gheeyoung Choe
- Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Jae-Kyung Won
- Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital
- Sung-Hye Park
- Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital
- Yong Kyu Lee
- Lieber Institute for Brain Development, Johns Hopkins Medical Campus
- Joo Heon Shin
- Lieber Institute for Brain Development, Johns Hopkins Medical Campus
- Chul-Kee Park
- Genomic Medicine Institute, Medical Research Center, Seoul National University
- Chae-Yong Kim
- Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital
- Jong-Il Kim
- Department of Biomedical Sciences, Seoul National University Graduate School
- DOI
- https://doi.org/10.1038/s12276-024-01204-3
- Journal volume & issue
-
Vol. 56,
no. 4
pp. 975 – 986
Abstract
Abstract We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on analyses of gene markers and CN tumor cells and postulate that CN tumorigenesis is due to dysregulation of radial glial cell differentiation into neurons. Our data demonstrate the potential role of FGFR3 as one of the leading drivers of tumorigenesis in CN.
