Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

Jiachen Zang; Hai Chen; Xiaorong Zhang; Chenxi Zhang; Jing Guo; Ming Du; Guanghua Zhao

doi:10.1038/s41467-019-08788-9

Nature Communications (Feb 2019)

Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

Jiachen Zang,
Hai Chen,
Xiaorong Zhang,
Chenxi Zhang,
Jing Guo,
Ming Du,
Guanghua Zhao

Affiliations

Jiachen Zang: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education
Hai Chen: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education
Xiaorong Zhang: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education
Chenxi Zhang: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education
Jing Guo: Center of Biomedical Analysis, Tsinghua University
Ming Du: School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University
Guanghua Zhao: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education

DOI: https://doi.org/10.1038/s41467-019-08788-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Shape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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