Nature Communications (Dec 2022)
Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation
- Xian Zhang,
- Songyuan Luo,
- Minjie Wang,
- Qiongqiong Cao,
- Zhixin Zhang,
- Qin Huang,
- Jie Li,
- Zhiyong Deng,
- Tianxiao Liu,
- Cong-Lin Liu,
- Mathilde Meppen,
- Amelie Vromman,
- Richard A. Flavell,
- Gökhan S. Hotamışlıgil,
- Jian Liu,
- Peter Libby,
- Zhangsuo Liu,
- Guo-Ping Shi
Affiliations
- Xian Zhang
- School of Food and Biological Engineering, Hefei University of Technology
- Songyuan Luo
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Minjie Wang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Qiongqiong Cao
- School of Food and Biological Engineering, Hefei University of Technology
- Zhixin Zhang
- School of Food and Biological Engineering, Hefei University of Technology
- Qin Huang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Jie Li
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Zhiyong Deng
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Tianxiao Liu
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Cong-Lin Liu
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Mathilde Meppen
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Amelie Vromman
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Richard A. Flavell
- Department of Immunobiology, Yale School of Medicine
- Gökhan S. Hotamışlıgil
- Department of Molecular Metabolism, Harvard School of Public Health
- Jian Liu
- School of Food and Biological Engineering, Hefei University of Technology
- Peter Libby
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Zhangsuo Liu
- Department of Nephrology, the First Affiliated Hospital, Research Institute of Nephrology, Zhengzhou University, Henan Province Research Center For Kidney Disease, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province
- Guo-Ping Shi
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-35256-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue. Authors here dissect the function of IL18 signalling in the adipose compartment by targeted genomic deletion of its two receptors individually and in combination in brown and white adipose tissues.
