Nature Communications (Mar 2023)
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks
- Jian Ma,
- Yingke Zhou,
- Penglin Pan,
- Haixin Yu,
- Zixi Wang,
- Lei Lily Li,
- Bing Wang,
- Yuqian Yan,
- Yunqian Pan,
- Qi Ye,
- Tianjie Liu,
- Xiaoyu Feng,
- Shan Xu,
- Ke Wang,
- Xinyang Wang,
- Yanlin Jian,
- Bohan Ma,
- Yizeng Fan,
- Yang Gao,
- Haojie Huang,
- Lei Li
Affiliations
- Jian Ma
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Yingke Zhou
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Penglin Pan
- Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Haixin Yu
- Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Zixi Wang
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Lei Lily Li
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Bing Wang
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Yuqian Yan
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Yunqian Pan
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Qi Ye
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Tianjie Liu
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Xiaoyu Feng
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Shan Xu
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Ke Wang
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Xinyang Wang
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Yanlin Jian
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Bohan Ma
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Yizeng Fan
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Yang Gao
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- Haojie Huang
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Lei Li
- Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University
- DOI
- https://doi.org/10.1038/s41467-023-37499-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
The retention of 53BP1 at DNA double strand breaks (DSBs) is inhibitory to homologous recombination repair. Following ionising radiation, the authors demonstrate that TRABID-mediated deubiquitination of 53BP1 promotes its retention, sensitising prostate cancer to PARP inhibition.
