Nature Communications (Oct 2018)

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

  • David R. Calabrese,
  • Xiang Chen,
  • Elena C. Leon,
  • Snehal M. Gaikwad,
  • Zaw Phyo,
  • William M. Hewitt,
  • Stephanie Alden,
  • Thomas A. Hilimire,
  • Fahu He,
  • Aleksandra M. Michalowski,
  • John K. Simmons,
  • Lindsey B. Saunders,
  • Shuling Zhang,
  • Daniel Connors,
  • Kylie J. Walters,
  • Beverly A. Mock,
  • John S. Schneekloth

DOI
https://doi.org/10.1038/s41467-018-06315-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivity