Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

Abstract

A practical synthesis of CPI-2850, the major metabolite of Devimistat (CPI-613® (6,8-bis-benzylsulfanyloctanoic acid)), has been developed to synthesize multigram quantities for enantiomeric separation. Using enantioenriched (S)-(−)-1,2,4-butanetriol pure (S)-CPI-2850 enantiomer was synthesized to identify the individual enantiomers after enantiomeric resolution. A slightly modified synthetic route was used to synthesize 13C-CPI-2850 useful for metabolic studies.

Keywords

• Devimistat
• CPI-613®
• CPI-2850
• Single enantiomers
• Enantioselective synthesis