Molecular genetic predictors of congenital infection in fetal growth restriction pregnancy

Abstract

Congenital infection is one of most frequent complications of early neonatal period in newborns with fetal growth restriction. The use of molecular genetic testing in this group of patients may promote the development of new methods of prophylaxis and treatment.Objective. To detect cytokines genes polymorphisms in pregnant women and newborns with fetal growth restriction and congenital infection. Materials and methods. The investigation of distribution of alleles and genotypes of cytokines genes polymorphic loci in 196 pairs «mother-newborn».Results. Congenital i nfection risk factors in pregnant women with fetal growth restriction are: chronic urinary tract diseases (chronic pyelonephritis and chronic cystitis), history of spontaneous abortion and hydramnios in current pregnancy. The presence of A/A IL10 gene polymorphism: -592 A > C in a newborn is associated with increased risk of congenital infection in pregnancies complicated by fetal growth restriction and chronic fetal hypoxia (p = 0,031,OR = 18.9 (1.7–215.2)).Conclusion: Results of the study suggest the use of clinical predictors for revealing the group of fetal growth restriction patients with high risk of congenital infection and subsequent genetic screening of newborns in this group of patients.

Keywords

• fetal growth restriction
• cytokines genes polymorphisms
• congenital infection