Vitamin D Level and its Relation with the Newly Diagnosed Diabetic Neuropathy in Women with Hypothyroidism

Abstract

Diabetic nephropathy has an important role in the kidneys’ function to remove extra fluid and waste products from the body. One way to avoid this disease is the treatment of other diseases, such as diabetes, thyroid gland diseases, and high blood pressure, in addition to maintaining a healthy lifestyle. This study aimed to find the relationship of thyroid hormone, blood biochemical parameters, and anthropometric measurement with the newly diagnosed diabetic neuropathy in women with hypothyroidism. In total, 90 women (with an age range of 35-55 years) were selected, 45 of whom were diagnosed with diabetic neuropathy and had hypothyroidism, and the other 45 were healthy women recruited as the control group. The following parameters were determined: serum triiodothyronine, thyroxine, thyroid stimulating hormone (TSH), 1,25-Dihydroxyvitamin D3 (DHVD3) activities, anthropometric measurement, fasting blood sugar (FBS), hemoglobin A1C (HbA1C), urea, creatinine, and lipid profile. The results showed a significant increase in the body mass index, blood pressure, TSH, FSB, HbA1C, urea, creatinine, and triglycerides of women with newly diagnosed diabetic neuropathy and hypothyroidism, compared to that in the control group (P≤0.05). A significant decrease was also observed in the high-density lipoprotein cholesterol, DHVD3, total triiodothyronine, and total thyroxine of women with newly diagnosed diabetic neuropathy and hypothyroidism, compared to that in the control group (P≤0.05). There was a correlation between vitamin D3 deficiency (VDD) and thyroid dysfunction in women with the newly diagnosed diabetic neuropathy, which indicated VDD is related to thyroid dysfunction and influences newly diagnosed diabetic neuropathy in women.

Keywords

• 1
• 25-dihydroxyvitamin d3
• glutathione reductase hyperthyroidism
• hypothyroidism