Nature Communications (Sep 2018)

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

  • Ian J. McGough,
  • Reinoud E. A. de Groot,
  • Adam P. Jellett,
  • Marco C. Betist,
  • Katherine C. Varandas,
  • Chris M. Danson,
  • Kate J. Heesom,
  • Hendrik C. Korswagen,
  • Peter J. Cullen

DOI
https://doi.org/10.1038/s41467-018-06114-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evolutionary conserved membrane remodelling complex for Wntless sorting and Wnt secretion.