Palladium-Catalyzed <i>N</i>-Alkenylation of <i>N</i>-Aryl Phosphoramidates with Alkenes

Abstract

Versatile and concise Pd-catalyzed oxidative N-alkenylation of N-aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O2 as a green oxidant and TBAB as an effective additive. An efficient catalytic system allows a variety of drug-related substrates to participate in these transformations, which is of great interest in the drug discovery and development of phosphoramidates.

Keywords

• palladium-catalyzed
• oxidative amination
• phosphoramidates
• alkenes
• O₂