Nature Communications (Nov 2017)

The genomic landscape of pediatric myelodysplastic syndromes

  • Jason R. Schwartz,
  • Jing Ma,
  • Tamara Lamprecht,
  • Michael Walsh,
  • Shuoguo Wang,
  • Victoria Bryant,
  • Guangchun Song,
  • Gang Wu,
  • John Easton,
  • Chimene Kesserwan,
  • Kim E. Nichols,
  • Charles G. Mullighan,
  • Raul C. Ribeiro,
  • Jeffery M. Klco

DOI
https://doi.org/10.1038/s41467-017-01590-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.