Nature Communications (Mar 2021)
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
- Anna Whitehead,
- Fynn N. Krause,
- Amy Moran,
- Amanda D. V. MacCannell,
- Jason L. Scragg,
- Ben D. McNally,
- Edward Boateng,
- Steven A. Murfitt,
- Samuel Virtue,
- John Wright,
- Jack Garnham,
- Graeme R. Davies,
- James Dodgson,
- Jurgen E. Schneider,
- Andrew J. Murray,
- Christopher Church,
- Antonio Vidal-Puig,
- Klaus K. Witte,
- Julian L. Griffin,
- Lee D. Roberts
Affiliations
- Anna Whitehead
- School of Medicine, University of Leeds
- Fynn N. Krause
- Department of Biochemistry, University of Cambridge
- Amy Moran
- School of Medicine, University of Leeds
- Amanda D. V. MacCannell
- School of Medicine, University of Leeds
- Jason L. Scragg
- School of Medicine, University of Leeds
- Ben D. McNally
- Department of Biochemistry, University of Cambridge
- Edward Boateng
- School of Medicine, University of Leeds
- Steven A. Murfitt
- Department of Biochemistry, University of Cambridge
- Samuel Virtue
- Institute of Metabolic Science, University of Cambridge
- John Wright
- School of Medicine, University of Leeds
- Jack Garnham
- School of Medicine, University of Leeds
- Graeme R. Davies
- Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- James Dodgson
- Phenotypic Screening and High Content Imaging, Antibody Discovery & Protein Engineering, R&D, AstraZeneca
- Jurgen E. Schneider
- School of Medicine, University of Leeds
- Andrew J. Murray
- Department of Physiology, Development and Neuroscience, University of Cambridge
- Christopher Church
- Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Antonio Vidal-Puig
- Institute of Metabolic Science, University of Cambridge
- Klaus K. Witte
- School of Medicine, University of Leeds
- Julian L. Griffin
- Department of Biochemistry, University of Cambridge
- Lee D. Roberts
- School of Medicine, University of Leeds
- DOI
- https://doi.org/10.1038/s41467-021-22272-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti-obesity effects in mouse models of obesity and diabetes.
