Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis

Abstract

Although there are some data concerning the nitric oxide and the cyclic 3'-5'guanosine monophosphate (cGMP) signaling pathway in trypanosomatids, there is no report about the cGMP-dependent enzymatic activity identification. In this sense, a cGMP dependent activity was detected on soluble fraction from Leishmania amazonensis promastigotes with a high metacyclic level. This information is valuable in order to explore the metabolic pathway of G kinase protein in this parasite.

Keywords

• Leishmania amazonensis
• cyclic 3'-5'-guanosine monophosphate
• metacyclogenesis