Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

Rochelle L. Coulson; Dag H. Yasui; Keith W. Dunaway; Benjamin I. Laufer; Annie Vogel Ciernia; Yihui Zhu; Charles E. Mordaunt; Theresa S. Totah; Janine M. LaSalle

doi:10.1038/s41467-018-03676-0

Nature Communications (Apr 2018)

Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

Rochelle L. Coulson,
Dag H. Yasui,
Keith W. Dunaway,
Benjamin I. Laufer,
Annie Vogel Ciernia,
Yihui Zhu,
Charles E. Mordaunt,
Theresa S. Totah,
Janine M. LaSalle

Affiliations

Rochelle L. Coulson: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Dag H. Yasui: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Keith W. Dunaway: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Benjamin I. Laufer: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Annie Vogel Ciernia: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Yihui Zhu: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Charles E. Mordaunt: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Theresa S. Totah: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California
Janine M. LaSalle: Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California

DOI: https://doi.org/10.1038/s41467-018-03676-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Many genes have oscillating gene expression pattern in circadian centers of the brain. This study shows cortical diurnal DNA methylation oscillation in a mouse model of Prader-Willi syndrome, and describes corresponding changes in gene expression and chromatin compaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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