The immune factors driving DNA methylation variation in human blood

Jacob Bergstedt; Sadoune Ait Kaci Azzou; Kristin Tsuo; Anthony Jaquaniello; Alejandra Urrutia; Maxime Rotival; David T. S. Lin; Julia L. MacIsaac; Michael S. Kobor; Matthew L. Albert; Darragh Duffy; Etienne Patin; Lluís Quintana-Murci; Milieu Intérieur Consortium

doi:10.1038/s41467-022-33511-6

Nature Communications (Oct 2022)

The immune factors driving DNA methylation variation in human blood

Jacob Bergstedt,
Sadoune Ait Kaci Azzou,
Kristin Tsuo,
Anthony Jaquaniello,
Alejandra Urrutia,
Maxime Rotival,
David T. S. Lin,
Julia L. MacIsaac,
Michael S. Kobor,
Matthew L. Albert,
Darragh Duffy,
Etienne Patin,
Lluís Quintana-Murci,
Milieu Intérieur Consortium

Affiliations

Jacob Bergstedt: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Sadoune Ait Kaci Azzou: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Kristin Tsuo: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Anthony Jaquaniello: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Alejandra Urrutia: HI-Bio
Maxime Rotival: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
David T. S. Lin: Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia
Julia L. MacIsaac: Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia
Michael S. Kobor: Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia
Matthew L. Albert: HI-Bio
Darragh Duffy: Institut Pasteur, Université Paris Cité, Translational Immunology Unit, Institut Pasteur
Etienne Patin: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Lluís Quintana-Murci: Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit
Milieu Intérieur Consortium

DOI: https://doi.org/10.1038/s41467-022-33511-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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