Nature Communications (Sep 2018)
Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
- Yanan Zhang,
- Jiancheng Wang,
- Weijun Huang,
- Jianye Cai,
- Junhui Ba,
- Yi Wang,
- Qiong Ke,
- Yinong Huang,
- Xin Liu,
- Yuan Qiu,
- Qiying Lu,
- Xin Sui,
- Yue Shi,
- Tao Wang,
- Huiyong Shen,
- Yuanjun Guan,
- Ying Zhou,
- Yuan Chen,
- Maosheng Wang,
- Andy Peng Xiang
Affiliations
- Yanan Zhang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Jiancheng Wang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Weijun Huang
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Jianye Cai
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Junhui Ba
- Department of Medical Intensive Unit, The Third Affiliated Hospital of Sun Yat-sen University
- Yi Wang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Qiong Ke
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Yinong Huang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Xin Liu
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Yuan Qiu
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Qiying Lu
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Xin Sui
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Yue Shi
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Tao Wang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- Huiyong Shen
- Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Yuanjun Guan
- Core Facility Center, Zhongshan Medical School, Sun Yat-Sen University
- Ying Zhou
- Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University
- Yuan Chen
- Center for Neurobiology, School of Medicine, Sun Yat-Sen University
- Maosheng Wang
- The Cardiovascular Center, Gaozhou People’s Hospital
- Andy Peng Xiang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-018-05808-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.
