PLoS Biology (Oct 2021)
AI delivers Michaelis constants as fuel for genome-scale metabolic models.
Abstract
Michaelis constants (Km) are essential to predict the catalytic rate of enzymes, but are not widely available. A new study in PLOS Biology uses artificial intelligence (AI) to accurately predict Km on a proteome-wide scale, paving the way for dynamic, genome-wide modeling of metabolism.