PLoS Biology (Oct 2021)

AI delivers Michaelis constants as fuel for genome-scale metabolic models.

  • Albert A Antolin,
  • Marta Cascante

DOI
https://doi.org/10.1371/journal.pbio.3001415
Journal volume & issue
Vol. 19, no. 10
p. e3001415

Abstract

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Michaelis constants (Km) are essential to predict the catalytic rate of enzymes, but are not widely available. A new study in PLOS Biology uses artificial intelligence (AI) to accurately predict Km on a proteome-wide scale, paving the way for dynamic, genome-wide modeling of metabolism.