EVALUATION OF TRAUMA SCORING AND ENDOTHELIAL GLYCOCALYX INJURY IN CATS WITH HEAD TRAUMA

Abstract

This study aim to evaluate the modified Glasgow Coma Scale (mGCS) and Animal Trauma Triage (ATT) scores, labo- ratory variables, and prognostic features of trauma-induced endothelial glycocalyx injury in cats with head trauma. Twenty-five cats with head trauma and 10 healthy cats were evaluated in this study. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the levels of syndecan-1 and thrombomodulin in the serum of the 25 cats with head trauma (within 48 hours) and the 10 healthy cats. In addition, mGCS scores, ATT scores, laboratory values, syndecan-1 and thrombomodulin levels were compared between the cats that survived following treatment and the cats that did not survive despite treatment. Syndecan-1 and thrombomodulin levels were not statistically different between healthy cats and cats with head trauma. In the cats with head trauma, the mGCS scoring system was found to be more sensitive than the ATT scoring system. In conclusion, syndecan-1 and thrombomodulin levels did not yield statistically significant results in the cats with head trauma. VREDNOTENJE SISTEMA OCENJEVANJA TRAVME IN POŠKODB ENDOTELIJSKEGA GLIKOKALIKSA PRI MAČKAH S POŠKODBO GLAVE Izvleček: Namen te študije je bil ovrednotiti spremenjeno glasgowsko lestvico kome (angl. Glasgow Coma Scale, GCS) in ocene ATT (Animal Trauma Triage), laboratorijske spremenljivke in prognostične značilnosti s travmo povzročene poškodbe endotelijskega glikokaliksa pri mačkah s poškodbo glave. V študijo je bilo vključenih 25 mačk s poškodbo glave in 10 zdravih mačk. Ravni sindekana-1 in trombomodulina v serumu 25 mačk s poškodbo glave (v 48 urah) in 10 zdravih mačk smo merili z encimsko imunoadsorpcijsko preiskavo (ELISA). Ocene mGCS, ocene ATT, laboratorijske vrednosti ter ravni sindekana-1 in trombomodulina smo primerjali med mačkami, ki so po zdravljenju preživele, in mačkami, ki kljub zdravljenju niso preživele. Vrednosti sindekana-1 in trombomodulina se med zdravimi mačkami in mačkami s poškodbo glave niso statistično razlikova- le. Pri mačkah s poškodbo glave se je sistem točkovanja mCGS izkazal za občutljivejšega od sistema točkovanja ATT. Zaklju- čili smo, da vrednosti sindekana-1 in trombomodulina pri mačkah s poškodbo glave niso statistično pomembne. Ključne besede: triaža poškodb živali; mačka; poškodba glave; spremenjena glasgowska lestvica kome; endotelijski glikokaliks

Keywords

• animal trauma triage
• cat
• head trauma
• modified Glasgow coma scale
• endothelial glycocalyx