TRPV1 activity and substance P release are required for corneal cold nociception

Fengxian Li; Weishan Yang; Haowu Jiang; Changxiong Guo; Andrew J. W. Huang; Hongzhen Hu; Qin Liu

doi:10.1038/s41467-019-13536-0

Nature Communications (Dec 2019)

TRPV1 activity and substance P release are required for corneal cold nociception

Fengxian Li,
Weishan Yang,
Haowu Jiang,
Changxiong Guo,
Andrew J. W. Huang,
Hongzhen Hu,
Qin Liu

Affiliations

Fengxian Li: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine
Weishan Yang: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine
Haowu Jiang: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine
Changxiong Guo: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine
Andrew J. W. Huang: Department of Ophthalmology & Visual Sciences, Washington University School of Medicine
Hongzhen Hu: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine
Qin Liu: Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, Washington University Pain Center, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-13536-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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