Communications Biology (Jan 2023)
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma
- Govind Pai,
- Khashayar Roohollahi,
- Davy Rockx,
- Yvonne de Jong,
- Chantal Stoepker,
- Charlotte Pennings,
- Martin Rooimans,
- Lianne Vriend,
- Sander Piersma,
- Connie R. Jimenez,
- Renee X. De Menezes,
- Victor W. Van Beusechem,
- Ruud H. Brakenhoff,
- Hein Te Riele,
- Rob M. F. Wolthuis,
- Josephine C. Dorsman
Affiliations
- Govind Pai
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Khashayar Roohollahi
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Davy Rockx
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Yvonne de Jong
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Chantal Stoepker
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Charlotte Pennings
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Martin Rooimans
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Lianne Vriend
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Sander Piersma
- OncoProteomics Laboratory, Cancer Center Amsterdam, Amsterdam University Medical Center
- Connie R. Jimenez
- OncoProteomics Laboratory, Cancer Center Amsterdam, Amsterdam University Medical Center
- Renee X. De Menezes
- Dept. Epidemiology and Biostatistics, Amsterdam University Medical Center
- Victor W. Van Beusechem
- Dept. of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center
- Ruud H. Brakenhoff
- Dept. of Otolaryngology, Head and Neck Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center
- Hein Te Riele
- Division of Tumor Biology and Immunology, Netherlands Cancer Institute
- Rob M. F. Wolthuis
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- Josephine C. Dorsman
- Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center
- DOI
- https://doi.org/10.1038/s42003-022-04389-3
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 12
Abstract
A genome-wide siRNA screen on patient-derived Fanconi anemia pathway-deficient head-and-neck squamous-cell-carcinoma (HNSCC) cell lines identifies RBBP9 as a candidate therapeutic target.
