Iron Status and Short-Term Recovery after Non-Severe Acute Myocarditis: A Prospective Observational Study
Paweł Franczuk,
Michał Tkaczyszyn,
Aneta Kosiorek,
Katarzyna Kulej-Łyko,
Kamil Aleksander Kobak,
Monika Kasztura,
Alicja Sołtowska,
Joanna Jaroch,
Piotr Ponikowski,
Ewa Anita Jankowska
Affiliations
Paweł Franczuk
Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Michał Tkaczyszyn
Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Aneta Kosiorek
Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Katarzyna Kulej-Łyko
Institute of Heart Diseases, University Hospital, 50-556 Wroclaw, Poland
Kamil Aleksander Kobak
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Monika Kasztura
Department of Food Hygiene and Consumer Health Protection, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
Alicja Sołtowska
Department of Cardiology, Tadeusz Marciniak Lower Silesia Specialist Hospital-Emergency Medicine Center, 54-049 Wroclaw, Poland
Joanna Jaroch
Department of Cardiology, Tadeusz Marciniak Lower Silesia Specialist Hospital-Emergency Medicine Center, 54-049 Wroclaw, Poland
Piotr Ponikowski
Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Ewa Anita Jankowska
Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland
Pathomechanisms responsible for recovery from acute myocarditis (MCD) or progression to non-ischemic cardiomyopathy have not been comprehensively investigated. Iron, positioned at the crossroads of inflammation and the energy metabolism of cardiomyocytes, may contribute to the pathophysiology of inflammatory myocardial disease. The aim of this study was to evaluate whether systemic iron parameters are related to myocardial dysfunction in MCD patients. We prospectively enrolled 42 consecutive patients hospitalized for MCD. Their iron status and their clinical, laboratory, and echocardiographic indices were assessed during hospitalization and during ambulatory visits six weeks after discharge. A control group comprising healthy volunteers was recruited. The MCD patients had higher serum ferritin and hepcidin and lower serum iron concentration and transferrin saturation (TSAT) than the healthy controls (all p p p < 0.05). In conclusion, in patients with acute MCD, iron status is altered and normalizes within six weeks. Low serum iron and TSAT are related to greater in-hospital neurohormonal activation and subtle persistent left ventricular dysfunction.
