Quorum sensing and its inhibition mechanisms

Abstract

The article is a brief literature review. This article provides an overview of the Quorum Sensing system in bacterial communities, highlighting the peculiarities of the system for gram-positive and gramnegative microorganisms. Basic information about the three existing Quorum Sensing systems is presented. Information is also given about different types of autoinducers, which are signaling molecules that trigger a cascade of behavioral reactions. The importance of the Quorum Sensing system as one of the fundamental mechanisms in the formation and regulation of bacterial biofilms is described, emphasizing the significance of biofilm microorganisms for modern clinical medicine and their impact on aggravating the issue of antibiotic resistance. The main mechanisms of inhibiting bacterial quorum, including by other microorganisms, are presented. The work discusses enzymatic and non-enzymatic methods of inhibiting the Quorum Sensing system, points of application and mechanisms of action. Some microorganisms with confirmed enzymatic activity by Quorum Quenching are indicated. Also presented are registered cases of suppression of other bacteria by microorganisms through the Quorum Sensing inhibitors system.