Frontiers in Chemistry (Sep 2023)

Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

  • Yuse Kuriyama,
  • Yusuke Sasano,
  • Yoshiharu Iwabuchi

DOI
https://doi.org/10.3389/fchem.2023.1251299
Journal volume & issue
Vol. 11

Abstract

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Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.

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