Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

Rengyun Liu; Tao Zhang; Guangwu Zhu; Mingzhao Xing

doi:10.1038/s41467-018-03033-1

Nature Communications (Feb 2018)

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

Rengyun Liu,
Tao Zhang,
Guangwu Zhu,
Mingzhao Xing

Affiliations

Rengyun Liu: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, John Hopkins University School of Medicine
Tao Zhang: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, John Hopkins University School of Medicine
Guangwu Zhu: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, John Hopkins University School of Medicine
Mingzhao Xing: Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, John Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-03033-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The mechanism of tumor progression robustly promoted by co-existing BRAF V600E and TERT promoter mutations is not known. Here, the authors show a mechanism of mutant TERT activation by BRAF V600E and MAPK pathways in which FOS, as a transcription factor of the GABPB promoter, functionally links the two oncogenes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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