Effects of a Curcumin/Silymarin/Yeast-Based Mycotoxin Detoxifier on Redox Status and Growth Performance of Weaned Piglets under Field Conditions
Vasileios G. Papatsiros,
Georgios I. Papakonstantinou,
Nikolaos Voulgarakis,
Christos Eliopoulos,
Christina Marouda,
Eleftherios Meletis,
Irene Valasi,
Polychronis Kostoulas,
Dimitrios Arapoglou,
Insaf Riahi,
Georgios Christodoulopoulos,
Dimitra Psalla
Affiliations
Vasileios G. Papatsiros
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece
Georgios I. Papakonstantinou
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece
Nikolaos Voulgarakis
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece
Christos Eliopoulos
Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece
Christina Marouda
Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Eleftherios Meletis
Laboratory of Epidemiology & Artificial Intelligence, Faculty of Public Health, School of Health Sciences, University of Thessaly, Terma Mavromichali St., 43100 Karditsa, Greece
Irene Valasi
Laboratory of Physiology, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece
Polychronis Kostoulas
Laboratory of Epidemiology & Artificial Intelligence, Faculty of Public Health, School of Health Sciences, University of Thessaly, Terma Mavromichali St., 43100 Karditsa, Greece
Dimitrios Arapoglou
Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece
Insaf Riahi
Biōnte Animal Nutrition, 43100 Reus, Spain
Georgios Christodoulopoulos
Department of Animal Science, Agricultural University of Athens, 75 Iera Odos Street, Votanikos, 11855 Athens, Greece
Dimitra Psalla
Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
The aim of this in vivo study was to investigate the effects of a novel mycotoxin detoxifier whose formulation includes clay (bentonite and sepiolite), phytogenic feed additives (curcumin and silymarin) and postbiotics (yeast products) on the health, performance and redox status of weaned piglets under the dietary challenge of fumonisins (FUMs). The study was conducted in duplicate in the course of two independent trials on two different farms. One hundred and fifty (150) weaned piglets per trial farm were allocated into two separate groups: (a) T1 (control group): 75 weaned piglets received FUM-contaminated feed and (b) T2 (experimental group): 75 weaned piglets received FUM-contaminated feed with the mycotoxin-detoxifying agent from the day of weaning (28 days) until 70 days of age. Thiobarbituric acid reactive substances (TBARSs), protein carbonyls (CARBs) and the overall antioxidant capacity (TAC) were assessed in plasma as indicators of redox status at 45 and 70 days of age. Furthermore, mortality and performance parameters were recorded at 28, 45 and 70 days of age, while histopathological examination was performed at the end of the trial period (day 70). The results of the present study reveal the beneficial effects of supplementing a novel mycotoxin detoxifier in the diets of weaners, including improved redox status, potential hepatoprotective properties and enhanced growth performance.
