Zanco Journal of Medical Sciences (Apr 2021)
Study of serum ceruloplasmin and zinc in type 2 diabetes mellitus
Abstract
Background and objective: Ceruloplasmin is the major copper-carrying protein in the blood and plays a role in iron metabolism. Zinc is an essential trace element for human health, which activates about 200 enzymes. This study aimed to evaluate the serum ceruloplasmin and zinc and the factor affecting them in type 2 diabetes. Methods: A case-control study was carried out from November 2018 to June 2019 in collaboration between the biochemistry unit at the College of Medicine and the biochemistry unit at the College of Nursing, Hawler Medical University. The study included 100 type 2 diabetic patients (group 1) and 100 healthy individuals (group 2) to evaluate the serum ceruloplasmin and zinc in both groups. Results: The mean value of serum ceruloplasmin was significantly (P <0.001) higher in type 2 diabetic patients (55.9 ± 1.26 mg/dL) than that of healthy individuals (36.65 ± 0.71 mg/dL). The mean value of serum zinc was significantly (P <0.001) lower in type 2 diabetic patients (39.19 ± 0.46 ug/dL) compared with controls (65.27 ± 2.5 ug/dL). There was a significant positive correlation between serum ceruloplasmin and the age of diabetic patients (P <0.001). There was a significant negative correlation between serum ceruloplasmin and serum zinc of diabetic patients (P <001). There was no significant correlation between serum ceruloplasmin and body mass index of diabetic patients (P = 0.928). Conclusion: Based on the findings of the present study, we concluded that high serum ceruloplasmin and low zinc were associated with type 2 diabetics.
Keywords
