ABCD: Arquivos Brasileiros de Cirurgia Digestiva (Jan 2022)

PROTOCOL FOR LIVER TRANSPLANTATION IN HILAR CHOLANGIOCARCINOMA

  • Lucas ERNANI,
  • Rodrigo Bronze de MARTINO,
  • Wellington ANDRAUS,
  • Eduardo de Souza Martins FERNANDES,
  • Felipe Pedreira Tavares de MELLO,
  • Ronaldo ANDRADE,
  • Leandro Savattone PIMENTEL,
  • Luciana Bertocco de Paiva HADDAD,
  • Fabricio Ferreira COELHO,
  • Paulo HERMAN,
  • Luiz Augusto Carneiro D’ALBUQUERQUE

DOI
https://doi.org/10.1590/0102-672020210002e1618
Journal volume & issue
Vol. 34, no. 3

Abstract

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ABSTRACT Background: Hilar cholangiocarcinoma represents more than half of all cholangiocarcinoma cases, having poor prognosis and presenting a median overall survival after diagnosis of 12-24 months. In patients who have unresectable tumors with a better prognosis, the proposal to perform liver transplantation emerged for expanding the possibility of free margins by performing total hepatectomy. Aim: To provide a Brazilian protocol for liver transplantation in patients with hilar cholangiocarcinoma. Method: The protocol was carried out by two Brazilian institutions which perform a large volume of resections and liver transplantations, based on the study carried out at the Mayo Clinic. The elaboration of the protocol was conducted in four stages. Result: A protocol proposal for this disease is presented, which needs to be validated for clinical use. Conclusion: The development of a liver transplantation protocol for cholangiocarcinoma aims not only to standardize the treatment, but also enable a better assessment of the surgical results in the future.

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