Nature Communications (Aug 2017)

Nucleolar expansion and elevated protein translation in premature aging

  • Abigail Buchwalter,
  • Martin W. Hetzer

DOI
https://doi.org/10.1038/s41467-017-00322-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals.